(2S,5R)-3,3-dimethyl-7-oxo-4- oxide-4-Thia-1-azabicyclo[3.2. 0]heptane-2-carboxylic Acid Diphenylmethyl Ester - Names and Identifiers
Name | BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE]
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Synonyms | Tazobactam Impurity 44 Tazobactam Acid Impurity 24 BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE] (2S,5R)-Benzhydryl 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2- (2S,5R)-Benzhydryl 3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid diphenylmethyl ester 4-oxide (2S,5R)-3,3-dimethyl-7-oxo-4- oxide-4-Thia-1-azabicyclo[3.2. 0]heptane-2-carboxylic Acid Diphenylmethyl Ester 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-, diphenylmethyl ester, 4-oxide, (2S,5R)-
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CAS | 87579-78-0
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(2S,5R)-3,3-dimethyl-7-oxo-4- oxide-4-Thia-1-azabicyclo[3.2. 0]heptane-2-carboxylic Acid Diphenylmethyl Ester - Physico-chemical Properties
Molecular Formula | C21H21NO4S
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Molar Mass | 383.46 |
Density | 1.37 |
Boling Point | 598.7±50.0 °C(Predicted) |
Solubility | Dichloromethane |
Appearance | Solid |
Color | Yellow |
pKa | -3.44±0.60(Predicted) |
Storage Condition | 2-8°C |
(2S,5R)-3,3-dimethyl-7-oxo-4- oxide-4-Thia-1-azabicyclo[3.2. 0]heptane-2-carboxylic Acid Diphenylmethyl Ester - Introduction
BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE [TAZOBACTAM INTERMEDIATE](BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE [TAZOBACTAM INTERMEDIATE]) is an organic compound with the chemical formula C19H15NO4S. Here are some of the properties of the compound:
Nature:
-Appearance: White crystalline solid
-Molecular weight: 357.39g/mol
-Melting point: 151-156°C
-Solubility: Insoluble in water, soluble in organic solvents such as ethanol, acetone and dimethyl sulfoxide
Use:
BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE] is a drug intermediate, mainly used to synthesize the antibiotic ceftaperidone (Tazobactam). Ceftamperone is a β-lactam antibiotic that is often used in combination with other antibiotics to enhance its efficacy against multidrug-resistant bacteria.
Preparation Method:
The preparation method of BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE] is relatively complicated, and in most cases, it needs to be synthesized by multi-step reaction. A common method is to start from penicillane (Penicillin) and go through several steps to finally obtain the target compound.
Safety Information:
Under the correct operation and storage conditions, BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE] is generally stable. However, as an organic compound, it may produce certain toxicity and irritation to human body. Therefore, appropriate laboratory practices should be followed during use and necessary personal protective measures should be taken, such as wearing gloves and goggles. If necessary, operate in a well-ventilated environment. When storing, it should be kept in a dry, cool place, away from fire and oxidant.
Last Update:2024-04-09 20:48:19